"L'Hôtel-Dieu de Lyon" is, in a subjective camera and in a single sequence shot of about twenty minutes, an exploration of the former Hôtel-Dieu hospital in Lyon. Located on the western edge of the Rhône and near Place Bellecour, the Hôtel-Dieu was rehabilitated and converted in 2018 into a luxury hotel and shopping malls. The film runs through all the inner courtyards of this huge building. The film is dedicated to François Rabelais who, from 1532, was a doctor at the Hôtel-Dieu in Lyon.