3 months after the events of Ghost-Spider: Veins of the Multiverse, Gwen Stacy (Ka'Janae White) is going through it. Having to live with Disgraced Sorcerer Supreme Wong (Novastar Kim) gets a bit tiring, and she is constantly spending her days hunting down multiversal entities to try and bring balance. Her life gets a bit more dramatic, however, when a new villian shows up, and Spider-Venom (Evan Reedell) is brought back into the equation. Gwen must fight to once again save the multiverse, but is she truly alone anymore?