"A shy but gentle man named Clifford Skridlow is a professor of comparative literature at the financially-strapped fictional Monroe College in Chicago. A chance encounter with four beautiful women at a restaurant changes his life forever."
Dan Aykroyd
as Clifford Skridlow / Doctor Detroit
Howard Hesseman
as Smooth Walker
Donna Dixon
as Monica McNeil
Lydia Lei
as Jasmine Wu
T.K. Carter
as Diavolo Washington
Lynn Whitfield
as Thelma Cleland
Fran Drescher
as Karen Blittstein
Kate Murtagh
as Mom
Nan Martin
as Margaret Skridlow
George Furth
as Arthur Skridlow
Peter Elbling
as Guptor
John A. Maloney
as Commodore
Pershing P. Anderson
as Stretch
William Munchow
as Professor Artel
Ed Meekin
as Professor Durant
Hank Salas
as Johnny
Rudolph Kovar
as Carson
Peter Aykroyd
as Mr. Frankman
Glenne Headly
as Miss Debbylike
Annabel Armour
as Airline Clerk
Robert Cornthwaite
as Professor Blount
Thomas O. Erhart Jr.
as Dean Swift
Parley Baer
as Judge
Oliver Clark
as Shaky Alcoholic Lawyer
Ben Kronen
as Bailiff
Lance Kinsey
as Street Dude
Andrew Duggan
as Harmon Rousehorn
Victoria Brown
as Mrs. Fulsom
Blackie Dammett
as Eddie Four Eyes
James Brown
as Bandleader
Alan Ruck
as Student
Marilyn Corwin
as Dancer (uncredited)
Sue Bowser
as Dream Girl
Robert Boris
Writer
Bruce Jay Friedman
Carl Gottlieb
Story
Michael Pressman
Director
Janet Brady
Stunts
Bernie Brillstein
Executive Producer
Joe La Placa
Hairstylist
Gina Rylander
Makeup Artist
Dee Crededio
Robert K. Weiss
Producer
Christopher Greenbury
Editor
Betsy Cox
Costume Design
Hal Gausman
Set Decoration
Wallis Nicita
Casting
Daniel C. Striepeke
Peter V. Herald
Unit Production Manager
Dione Taylor
Jerry O'Dell
Norma Lee
Associate Producer
Lawrence G. Paull
Production Design
King Baggot
Director of Photography
Lalo Schifrin
Original Music Composer
Brian Smith
Grip